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KMID : 0861020060210030103
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Korea Journal of Herbology
2006 Volume.21 No. 3 p.103 ~ p.109
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Extrat of Xanthii Fructus down-regulate TLR-4 mediated murine peritoneal macrophage inflammatory response by limiting NO synthase and $IkB-{\alpha}$ degradation
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Jung Won-Seok
Seo Sang-Wan
Cho Joon-Ki
Son Ji-Woo
Park Min-Cheol
Choi Chang-Min
Yeom Seung-Ryong
Hwang Sang-Wook
Kim Yong-Woo
Song Dal-Soo
Chae Young-Seok
Choi Won-Seok
Noh Jung-Eun
Yun Han-Ryoung
Kim Yeong-Mok
Park Sung-Joo
Shin Min
Song Ho-Joon
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Abstract
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Objectives : The purpose of this study was to investigate the TLR-4 mediated anti-inflammatory effects of extract from Xanthii Fructus(XF) on the peritoneal macrophage.
Methods : To evaluate of TLR-4 mediated inflammatory of XF, we examined NO and cytokine production in TRL-4 ligand(LPS-lipopolysacchride) induced macrophages. Furthermore, we checked molecular mechanism using western blot.
Results : l.Extract from XF reduced LPS-induced Nitric oxide (NO), tumor necrosis factor-a (TNF-a), interleukin (IL)-6 and IL-12 production in peritoneal macrophages 2.Extract from XF itself does not have any cytotoxic effect.XS inhibited degradation of IkBa in the TLR-4 mediated peritoneal macrophages
Conclusion : XF down-regulated TLR4 ligand(LPS)-induced NO and cytokine productions.
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KEYWORD
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Xanthii Fructus(XF), lipopolysaccharide (LPS), Toll like receptor(TLR) inflammation
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